Grymes Hill is a 374 feet (114 m) tall hill formed of serpentine rock on Staten Island, New York.[1] It is the second highest natural point on the island and in the five boroughs of New York City. The neighborhood of the same name encompasses an area of 0.894 square miles (2.32 km2) and has a population of 8,263 people. The hill also includes parts of the Silver Lake neighborhood. The area includes part of ZIP Codes 10301 and 10304.

Neighborhoods around Grymes Hill include Ward Hill to the north, Silver Lake to the west, Sunnyside and Emerson Hill to the south, to the southeast is Concord, and Stapleton and Stapleton Heights to the east. The east side of the hill is defined by Van Duzer Street and Richmond Road to the intersection with the Staten Island Expressway, which, with Clove Road, defines the southern side. On the west is Victory Boulevard. Some claim Cebra Avenue for the northern border, while others believe that the border is Louis Street.

Grymes Hill is the home of two institutions of higher learning: Wagner College, and the Staten Island campus of St. John's University. The St. John's campus of 16.5 acres (67,000 m2) was originally a small Catholic women's institution, Notre Dame College, which closed in 1971, when St. John's University took over the campus. Also on the hill is Notre Dame Academy, a Roman Catholic elementary and high school for girls which received an overall A Grade by Niche.

Adjacent to (and owned by) Wagner College is the site of a former Roman Catholic high school, named Augustinian Academy after the order of friars who ran it; the school closed in 1969. Near the foot of the hill, on Foote Avenue, is P.S. 35, the Clove Valley School, a K-5 school which is ranked 10 out of 10 by GreatSchools.org, 85th of 2,395 New York elementary schools according to SchoolDigger and received an overall A Grade by Niche. Also located on Grymes Hill is Casa Belvedere, a center for Italian culture and studies in Italian language and culture which is located in the Louis A. and Laura Stirn House which was listed on the National Register of Historic Places in 2010, and designated a NYC Landmark in 2001.